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References Pickart, L., & Margolina, A

For example, these mediators, increase RANKL expression in stromal/osteoblastic cells or by sensitizing precursors to RANKL stimulation ( Estrogen plays a critical regulatory role in osteoclastogenesis primarily through modulation of the RANKRANKL signaling pathway

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Therefore, damage to the glutathione system may lead to proinflammatory-induced oxidative stress in chondrocytes, especially in the process of senescence (McCutchen et al., 2017

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